Chemistry for Drug Discovery [2014-2015] [SEM 2]

Chemistry skills and background necessary for drug discovery

Druggable Systems [2014-2015] [SEM 2]

Introduction to Modelling Biological Systems [2014-2015] [SEM 2]

Drugs designed against a specific target don’t always work as they were intended.  In particular, when a drug target is part of a pathway, its inhibition often isn’t as effective as was predicted from the properties of the protein in isolation.  This course will start by illustrating the kinetic properties of two potential target enzymes in situations when they are working in isolation.  It will then move on to introduce kinetic modelling of a system of enzymes in which the system has emergent properties that were not obvious from the behaviour of the individual components. The effects of putative inhibitors will be explored.

 

Structure Determination of Drug Targets [2014-2015] [SEM 2]